Pathway-Specific Dopamine Abnormalities in Schizophrenia
نویسندگان
چکیده
منابع مشابه
Presynaptic dopamine in schizophrenia.
Presynaptic dopamine (DA) transmission has been measured in schizophrenia using different paradigms aimed at providing estimates of the integrity or the activity of the presynaptic dopaminergic neuron. RESEARCHERS HAVE MEASURED: (1) DA synthesis capacity with [(18) F]DOPA, a measure of the activity of dopa decarboxylase, (2) DA release with studies measuring the impact of a DA releasing stimula...
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The theory that alterations of dopaminergic synaptic transmission may play a role in the pathogenesis of schizophrenia is widely accepted. A more recent theory links the endorphin system to the etiology of schizophrenia. We propose that these two theories may be combined into a single model. Recent neurochemical and pharmacological findings have indicated close functional relationships between ...
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202 Introduction Dopamine systems have long been implicated in schizophrenia and its treatment. There is, however, little evidence for a primary abnormality of dopaminergic innervation in the disease, although subtle neuronal deficits, for which there is substantial evidence in the brain in schizophrenia, could conceivably affect dopaminergic neurotransmission in an indirect manner. However, do...
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ژورنال
عنوان ژورنال: Biological Psychiatry
سال: 2017
ISSN: 0006-3223
DOI: 10.1016/j.biopsych.2016.03.2104